Manchester United and Tottenham Hotspur have been handed home starts to their Europa League campaigns, while Rangers will travel to Malmo for their opening match.
FA Cup winners United meet Dutch side Twente on 25 September, with Rangers playing in Sweden on the following day, when Spurs face Qarabag of Azerbaijan.
Rangers' first home match is against Lyon in the following week, on 3 October, when Manchester United visit Porto and Spurs go to Ferencvaros of Hungary.
The Red Devils will also face former United boss Jose Mourinho when they go to Fenerbahce on matchday three, 24 October.