Real Madrid's Raphael Varane has joined Gareth Bale and Keylor Navas on the injured list for Wednesday's Champions League fixture against Tottenham, but Isco has been named in the travelling squad despite missing training on Monday.
Varane picked up an adductor muscle issue in Sunday's shock 2-1 La Liga defeat at Girona, with Isco also suffering a thigh problem late in the game.
Ex-Tottenham winger Bale and Navas will also miss the trip to Wembley, with neither having recovered from their respective injuries in time.
Confirmation of the absences came before Zinedine Zidane's side flew out to London for a game which could decide who tops Group H and is seeded in the round of 16.