The summer signing from Deportivo La Coruna netted a hat-trick against FC Basel to help his side top Group A in the Champions League, following Paris Saint-Germain's draw with Ludogorets'.
The 28-year-old had only previously scored twice for the north Londoners - against Nottingham Forest in the EFL Cup - but he started in Switzerland and reaped the rewards.
He scored twice in the opening 16 minutes as Arsenal raced into an early lead, before completing his treble just two minutes into the second half.
With the consistency of Arsene Wenger's attack this season, it has been difficult for Perez to settle into the Gunners' side, but that will have eased his position going into the Christmas period.