Hull look set to be without Evandro, Harry Maguire and Abel Hernandez because of injuries.
They join Will Keane, Lazar Markovic, Ryan Mason, David Meyler and Moses Odubajo on the sidelines.
Tottenham await news on whether full-backs Kieran Trippier and Kyle Walker will be fit to return.
Christian Eriksen is likely to be recalled after being rested against Leicester on Thursday, while Filip Lesniak could be handed a start.
MOTD COMMENTATOR'S NOTES
Martin Fisher: "On the final day of last season, Tottenham travelled to an already relegated club and lost 5-1.