Tottenham goalkeeper and captain Hugo Lloris will miss their final four games of the season because of a thigh issue.
The former France international, 36, has not featured since being withdrawn at half-time in Tottenham's 6-1 defeat at Newcastle on 23 April.
"Hugo is out for the season. We have now had the results back. We did fear that," said interim boss Ryan Mason.
Tottenham are seventh in the Premier League going into Saturday's home match against Crystal Palace.
Fraser Forster is likely to deputise after replacing Lloris against Newcastle and starting the club's last two matches, against Manchester United and Liverpool.