Tottenham Hotspur announced on Thursday that striker Harry Kane suffered "significant lateral ligament injury" to his left ankle, while Dele Alli broke his hand against Manchester City on Tuesday.
The two players picked up the injuries during the club's UEFA Champions League quarter-final first leg win over Pep Guardiola's side. Heung-min Son scored the only goal of the game in a 1-0 victory.
Tottenham have not put a date on when Kane might return to action, but Alli "will be assessed" to see if he can feature in Tottenham's Premier League fixture against Huddersfield Town on Saturday.