Bye weeks are a great equalizer in fantasy football. The Lions, Texans, Raiders, and Titans don't play in Week 6. The Lions need time off to get D'Andre Swift and Amon-Ra St. Brown healthy. Based on the play through the first five games, fantasy teams will need to find replacements for these top players:
Running Back: Dameon Pierce, Josh Jacobs, Derrick Henry
Wide Receiver: Brandin Cooks, Davante Adams, Hunter Renfrow
Tight End: Darren Waller
I didn't include the already mentioned Lions' players and all of the starting quarterbacks from Detroit, Tennessee, Houston, and Las Vegas are more likely QB2 for most fantasy football teams.