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Week 5 NFL Picks: Spread Advice, Best Odds and Full Game Predictions

A division matchup between two teams with 3-1 records—what better way to start Week 5 of the NFL season?

In what should be one of the best games of the week, the Seattle Seahawks host the Los Angeles Rams on Thursday night in an NFC West rivalry contest. With the San Francisco 49ers in first place in the division at 3-0, this Rams-Seahawks matchup could be key for positioning heading into the rest of the season.

Week 5 will also feature the New England Patriots, Kansas City Chiefs and 49ers all looking to stay undefeated, as well as an exciting NFC matchup between the Green Bay Packers and Dallas Cowboys.