To start or to sit. This is a question that plagues fantasy managers on a weekly basis, and this year's rash of high-profile injuries has not made decisions any easier.
Players like Saquon Barkley, Christian McCaffrey, Michael Thomas and Julio Jones are must-starts when healthy. Of course, these players aren't or haven't been healthy, which has led managers to start more second-tier players than is ideal.
It's this second tier where there are legitimate decisions to be made. You're not taking Patrick Mahomes or Josh Jacobs out of the lineup unless he is on bye, but deciding whether to start Matthew Stafford or Nyheim Hines in a given week is trickier.