The third-place 49ers (8-6) head east to face the AFC South-leading Titans (9-5) for Thursday Night Football.
- Moneyline: San Francisco (-188) |Tennessee (+155)
- Spread: San Francisco -3.5 (-110) | Tennessee +3.5 (-110)
- Total: 44 -Over (-110) | Under (-110)
- Game Info: Dec. 23, 2021 | 8:20 p.m. ET | NFL Network
Tennessee is coming off a tough loss to Pittsburgh on Sunday and will be looking to rebound against a San Francisco team looking to extend its win streak to three.
The Titans have had a tough go of it lately.