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Week 10 NFL Picks: Tips, Odds and Over/Under Predictions for Sunday

As advertised, the NFL's Week 10 slate is going to be one of the season's toughest.

Look at Thursday, where a Pittsburgh Steelers team welcomed the strong Carolina Panthers to town on a short week while favored by only four points.

The Steelers quickly turned it into a 52-21 blowout, hurting plenty of bettors in a single swoop—especially those who thought Cam Newton's strong stretch would include beating up on a bad Steelers defense.

So goes the pitfalls of being this late in the season. Out in the cold, bad teams shrivel and contenders keep heating up, something we'll see again across a slate littered with huge lines and tough decisions for would-be bettors.