The optimism over Jimmy Garoppolo's calf injury earlier this week didn't lead to him practicing.
And it will result in Trey Lance making his first career start.
Garoppolo was not present at the beginning of San Francisco 49ers practice on Friday, according to reporters who cover the team. He missed all three practices this week. That means Lance, the third overall pick of the draft, will start Sunday at the Arizona Cardinals.
#49ers QB Trey Lance will make his first NFL start Sunday against the Arizona Cardinals, coach Kyle Shanahan says.