The Arizona Cardinals had no chance, and it had nothing to do with Kyler Murray not playing.
Defenses will have a problem with the 49ers this season. The Cardinals were helpless to stop everyone the 49ers could throw at them. Christian McCaffrey didn't even score and the 49ers put up five touchdowns. Brandon Aiyuk scored two. George Kittle also scored two. Deebo Samuel scored after taking a handoff and cruising down the sideline, which has become a trademark of his.
Jimmy Garoppolo doesn't have to do much but get the ball out and watch his all-star teammates run to the end zone.