Back to the Top News Newsfeed

San Francisco 49ers vs. Kansas City Chiefs Odds, Analysis, NFL Betting Pick

The Kansas City Chiefs are 8-3 both straight up and against the spread over their last 11 home games. The San Francisco 49ers are only 4-10 SU but 9-5 ATS their last 14 times out on the road. Where might the smart money reside for Sunday afternoon's Niners-Chiefs battle at Arrowhead Stadium?

NFL point spread: The Chiefs opened as 4.5-point favorites; the total was 52.5 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)

NFL betting pick, via OddsShark computer: 28.5-21.8 Chiefs (NFL picks on every game)

Check out the OddsShark podcast on iTunes or at OddsShark.