wide receiver is "expected to miss some game action" as a result of a knee injury, according to Jeff Howe of The Athletic.
He was absent from practice Thursday, potentially setting him up to miss his first game since 2018.
Howe added the 34-year-old could get surgery to fix the injury, although it's not expected to cost him the rest of the regular season.
In his 12th NFL season, Edelman is playing for the first time without Tom Brady as his primary quarterback in 2020. He's coming off a season in which he posted 100 receptions and a career-high 1,117 yards as one of the few pass-catchers Brady trusted.