49ers star tight end George Kittle is expected to miss eight weeks with a broken bone in his left foot, according to ESPN's Adam Schefter.
According to NFL Network's Ian Rapoport, he will be placed on injured reserve.
Kittle appeared to injure his foot early in the fourth quarter of Sunday's eventual 37-27 defeat to the Seahawks when the Iowa product leaped to catch a 25-yard pass from quarterback Nick Mullens.
The two-time Pro Bowler tight end came down awkwardly and hobbled to the sidelines.
Kittle finished with two catches for 39 yards in the loss.