No. 16 Syracuse will look to rebound from its first loss of the season to No. 5 Clemson when it welcomes Notre Dame to central New York.
The Orange have been a lucrative team to invest in at home, covering the spread in nine of the last 11 home games (81.8%). Syracuse is 5-0 straight-up (SU) and 4-1 against the spread (ATS) at home this season and welcomes an Irish squad fresh off a 44-21 thumping of UNLV to JMA Wireless Dome.
Notre Dame has won four of its last five game but is an underdog for only the second time this season.