Tom Brady and Aaron Rodgers go head-to-head, Tua Tagovailoa will get his stiffest challenge yet against the Bills, and the Cowboys will try to hand the Giants their first loss.
Week 2 was a wild one. Underdogs went 10-4 against the spread, and seven won their games straight up, with some improbable second-half (and even final-minute-and-a-half) comebacks.