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N.F.L. Week 16 Predictions: Our Picks Against the Spread

The N.F.L. playoff picture should come into sharp focus this weekend, with several division titles and wild-card spots likely to be decided. There will be games on Friday, Saturday, Sunday and Monday, and while a few of them are irrelevant, most can have an impact on the standings.

Here is a look at N.F.L. Week 16, with all picks made against the spread.

Overall record: 110-107-7

Sunday’s Best Games

Indianapolis Colts at Pittsburgh Steelers, 1 p.m., CBS

The Colts (10-4) have seemed better than the Steelers (11-3) for much of this season — and the team’s records are getting closer to reflecting that.