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NFL Week 16 Picks: Game Odds, Props, Lines and Over-Under Predictions

The NFL Week 16 schedule is littered with intriguing matchups, and with those games come some interesting betting lines.

The two games in marquee time slots Sunday possess the two largest over-under lines of the week, while the game to watch Saturday sits right in the middle of the total points lines.

In addition to the pair of plus-50 over-under lines Sunday, there's two marks set under the 40-point threshold.

Other than those four outliers, the over-under lines for Week 16 are similar, as most of them reside in the low-to-mid 40s.

Week 16 Schedule and Odds

All Times ET.