The N.F.L. said Tuesday that it would play at least three regular-season games over the next three years at Twickenham Stadium in London, the latest venue to host the league in Britain.
By agreeing to play at Twickenham, which is controlled by the Rugby Football Union, the league has signaled that it plans to play a fourth regular-season game in London as soon as next season.
Since 2007, when the league began playing regular-season matchups in London, every game has been played in Wembley Stadium, including three matchups this season.
The N.F.L. had said it was considering playing more games in London each year.