Barring a tie, another winless team will earn a victory in Week 5. The New York Giants or Los Angeles Chargers could use the win as a springboard back into divisional competition for the remainder of the season.
Thus far, the Kansas City Chiefs have looked impressive in the primetime slot. Will they win their third game on the national stage?
There's intriguing quarterback news for several teams.
Chicago Bears rookie quarterback Mitchell Trubisky will make his NFL debut, per ESPN's Adam Schefter and Dan Graziano. In the same game, Minnesota Vikings quarterback Sam Bradford could return to action for the first time since Week 1.