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NFL Predictions Week 1: Picks and Odds Advice for Opening Schedule

Week 1 got off to a rousing start, as the Kansas City Chiefs rocked the Houston Texans in a 34-20 beatdown. Kansas City covered what was a sizeable late spread of nine points, though settled for a late field goal that helped push the score under the 54.5-point threshold.

While Thursday night's opener wasn't close, that's not going to be the case for every game on the remaining slate. There are some tough decisions to be made, especially with lines considered.

Here, we'll run down the latest odds and over/unders from DraftKings Sportsbook, make score predictions for each game and examine some of our top plays heading into Sunday.