The New England Patriots (3–1) are coming off their first loss on Sunday, as they were blanked at home for the first time since 1993 when the Buffalo Bills (2–2) pulled off a 16–0 upset as 3.5-point road underdogs.
The betting line moved in Buffalo’s favor leading up to kickoff with Jacoby Brissett starting at quarterback, but the return of Tom Brady in Week 5 versus the winless Cleveland Browns will likely see action the other way after New England opened as a 10-point favorite at sportsbooks monitored by OddsShark.com.
The Browns (0–4) remain the only team in the NFL without a victory after falling 31–20 to the Washington Redskins as 7.