Football bettors often have a few systems they follow, even if they aren't doing it cognitively. Some bettors love backing teams coming off ugly losses while others will always make sure to fade a West Coast team playing in the early time slot. Some of these trends are currently more profitable than others, but at one point, they all were moneymakers. That's why we started following them in the first place.
With the expansion of "Thursday Night Football" over the past 15 or so years, many were quick to realize that home teams were profitable on Thursday nights.