Drew Brees holds the edge in the quarterback rivalry with Cam Newton, winning eight of 14 head-to-head matchups straight up, including the last three in a row. And Brees' New Orleans Saints are 9-5 against the spread over that span against Carolina. Brees and Newton face off for the 15th time on Monday night in Charlotte.
NFL point spread: The Saints opened as 6.5-point favorites; the total was 54.5 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 31.