star won't play in Sunday's marquee matchup with the Kansas City Chiefs.
The Saints announced their All-Pro wide receiver will miss the game with an ankle injury.
The three-time Pro Bowler has had a season to forget. He injured his ankle in New Orleans' Week 1 victory over the Tampa Bay Buccaneers and picked up a hamstring injury in October as he neared a return.
Thomas also received a one-game suspension after fighting with teammate C.J. Gardner-Johnson and causing minor problems behind the scenes for the team.
The 27-year-old set a single-season record for receptions (149) in 2019, his third straight campaign with 100-plus catches.