Back to the Top News Newsfeed

Los Angeles Rams vs. San Francisco 49ers NFL Week 10 Odds, Plays and Insights

NFC West opponents meet when the Los Angeles Rams (-4.5)

(7-2) visit the San Francisco 49ers (+4.5) (3-5) on Monday, November 15, 2021 at Levi's Stadium. Los Angeles is favored by 4 points. The over/under is set at 49 points for the game.

For more great betting and fantasy insight, join the SI Winners Club Newsletter.

Odds for Rams vs. 49ers

Over/under insights

  • Los Angeles' games this season have gone over 49 points five of 11 times.
  • San Francisco's games have gone over 49 points in five of 10 chances this season.