quarterback will return to the starting lineup Sunday after missing the previous two games with a high ankle sprain suffered in Week 2 against the .
Head coach Kyle Shanahan announced the news Friday, per ESPN's Adam Schefter.
Garoppolo, 28, has completed 67.3 percent of his passes for 390 yards, four touchdowns and no interceptions this season.
With Garoppolo out, the 49ers turned to Nick Mullens, who led the team to a 36-9 win over the New York Giants in Week 3. The 49ers lost 25-20 to the Philadelphia Eagles in Week 4.