San Francisco 49ers head coach Kyle Shanahan told reporters quarterback Jimmy Garoppolo will miss Sunday's game against the Arizona Cardinals with a calf injury.
That means rookie quarterback Trey Lance will start.
The 29-year-old Garoppolo suffered a calf injury earlier this season during a loss to the Seattle Seahawks and has dealt with physical setbacks in the past. He played just six games in 2020 because of ankle concerns and appeared in three games in 2018 due to a torn ACL.
His last fully healthy season was when he helped lead the 49ers to the Super Bowl in 2019 by completing 69.