The Indianapolis Colts (10-6) will try to continue their dominance of the Houston Texans (11-5) on Saturday when they visit NRG Stadium as small road underdogs at sportsbooks. The Colts are 26-8 straight up in the past 34 meetings with the Texans, according to the OddsShark NFL Database, covering the spread in three of the last four.
NFL point spread: The Texans opened as three-point favorites; the total was 47.5 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 25.