A number of the league's biggest names suffered injuries throughout Week 2 action.
Here are some of the notable injuries we are keeping track of:
Saquon Barkley, Giants — Knee (Out)
Giants star running back Saquon Barkley was helped off the field early in the second quarter of New York's matchup with the Bears. Later, Barkley was carted back to the locker room for x-rays and the team later ruled him out with a knee injury.
More on Barkley's injury from GiantsCountry: Saquon Barkley Leaves Giants-Bears Game with a Knee Injury