San Francisco 49ers rookie quarterback Trey Lance won't have his most dangerous offensive weapon in his first start. Tight end George Kittle was placed on Injured Reserve on Saturday due to a calf injury.
Kittle will miss at least three games due to the issue. The 49ers believe rest will alleviate the issue, allowing Kittle to return once his IR stint ends.
Kittle first appeared on the injury list ahead of the team's Week 3 game. The injury caused Kittle to miss practice two out of three days before Week 3 and Week 4.