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Friday’s March Madness Sweet 16 Best Bets and Odds: Expect Underdogs To Dominate

On Friday, Sweet 16 action will tip off from Philadelphia and Chicago highlighted by three double-digit seeded teams and a Blue Blood that was assigned as an 8-seed but is playing like a 1-seed. Among the eight clubs in action is this year’s Cinderella looking to make men’s NCAA tournament history by becoming the first 15-seed to ever advance to the Elite Eight just 92 miles from their campus.

Sports bettors who have backed underdogs in the opening rounds of the tournament have experienced sizable returns on their investments.

Now, the question becomes: Does that trend continue in the Sweet 16?