One lineup decision can make or break your fantasy football week, and in the middle of the season, it could affect your shot at a high spot in the playoffs.
The decision-making process doesn't get any easier in Week 6, as you have to navigate a growing injury list, especially at tight end, and maneuver through bye weeks.
Digging through the waiver wire for ideal replacements at each position can be a painful exercise, especially when you start to second guess yourself Sunday morning.
Among the best pickups for Week 6 are a returning quarterback, receivers looking to benefit from offensive outbursts and a running back trying to take advantage of an expanded opportunity.