A fantasy football draft is a little bit like the real thing; you can mess up with your first pick and still win, but it makes the job a lot harder.
If you're selecting in the first half of the opening round, swinging and missing with your top selection—whether it's your fault or due to factors outside your control—could be a massive blow.
For instance, Arizona Cardinals running back David Johnson was universally regarded as one of the best fantasy players entering the 2017 season. Then he suffered a wrist injury in the opening week and missed the rest of the year.