San Francisco 49ers running back Elijah Mitchell suffered a knee injury in Sunday's season opener against the Chicago Bears and was ruled out for the remainder of the game, the team announced.
Mitchell had six carries for 41 yards before exiting.
It's a tough blow for Mitchell, who was in and out of the lineup in his rookie year because of knee, shoulder and rib injuries. The sixth-round pick out of Louisiana also missed time with a concussion.
In 11 games last season, he rushed for 963 yards and five touchdowns and also caught 19 passes for 137 yards and one score.