If you're a fan of defensive football, then the matchup between the Commanders and 49ers is the game for you. Both teams have strong defenses, with San Francisco ranking No. 1 in both fewest points allowed per game and fewest yards allowed per game.
When it comes to betting, the 49ers have the edge, with a 9-5 record against the spread compared to Washington's 7-6-1 ATS record. The 49ers have also covered the spread in their last five games, making them a strong pick for bettors.
San Francisco is an even stronger bet when listed as a home favorite, a role they have succeeded in with a 5-1 ATS record.