Two teams dealing with major injury issues at the running back position will kick off Week 5 on Thursday Night Football when Russell Wilson and the Broncos host Matt Ryan and the Colts.
Wilson, who is 106-55-1 in his career, has dropped outside the top ten in MVP futures at SI Sportsbook at +3500 odds. Wilson, who has struggled to meet expectations in his first season in Denver, has fallen behind quarterbacks like Trevor Lawrence and Kirk Cousins in the betting market.