USC's matchup against Colorado on Saturday has been canceled, the Pac-12 announced on Thursday.
The contest was canceled due to numerous positive tests within the Trojans' program, per the Pac-12. Saturday's game will not be rescheduled.
"Not contesting this game is very disappointing to our student-athletes and our fans," the Pac-12 said in a statement. "While all of us want to see our football student-athletes on the field competing, our number one priority must continue to be the health and safety of all those connected to Pac-12 football programs."
USC announced its first positive test in the football program on Tuesday.