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College Football Week 13 Picks: Michigan-Ohio State Headlines Rivalry Week

The final week of the 2021 college football regular season is here, and it's headlined by arguably the year's biggest game yet—No. 2 Ohio State vs. No. 5 Michigan in Ann Arbor.

The Big Ten East foes will renew their storied rivalry after the 2020 edition was canceled due to a COVID-19 outbreak. The Buckeyes have won eight straight in the series, including all five of the Jim Harbaugh era at Michigan. This year's matchup could be a playoff eliminator, with both teams coming in at 10–1. No two-loss team has ever made the CFP.