Arsenal, which has qualified for 16 straight Champions League knockout rounds, but has made only one final and never won, has a difficult road again after drawing Barcelona in the round of 16 on Monday.
Arsenal needed a 3-0 victory at Olympiakos last week to keep its streak alive, and now must play the defending champions and favorites.
Manchester City got an easier draw against Dynamo Kiev. No eastern European team has made a Champions League final since 1991. The first leg will be played in Kiev in front of an empty stadium because of racist incidents by fans there.