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Buffalo Bills vs. Jacksonville Jaguars Odds, Wild Card NFL Betting Pick

The Buffalo Bills (9-7) will attempt to win in the state of Florida for the second time in as many weeks when they visit the Jacksonville Jaguars (10-6) as big road underdogs at the sportsbooks for Sunday's AFC Wild Card matchup.

The Bills made the playoffs for the first time since 1999 by beating the Miami Dolphins 22-16 last Sunday and got some help from the Baltimore Ravens, who lost 31-27 to the Cincinnati Bengals.

NFL point spread: The Jaguars opened as 6.5-point favorites; the total was 41 early in the week, according to sportsbooks monitored by OddsShark.