The Bills will be without one of their top scoring threats to start the 2016 season.
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Running back Karlos Williams has been suspended the first four games by the NFL for violating the league's substance abuse policy, the team announced Friday.
"As an organization, we are disappointed that Karlos has put himself in this situation," the Bills said in a statement. "Poor decisions such as this affect not only the individual, but the entire Bills organization. We will continue to work with Karlos through the various player programs we provide to assist him in making better decisions moving forward.