Going into last season the Arizona Cardinals owned a 5-2 run both straight up and against the spread in its NFC West rivalry with the Los Angeles Rams. But the Rams swept the season series from the Cardinals last year, easily covering the spread both games, as these teams traded places in the NFC hierarchy. Los Angeles is a double-digit favorite for Sunday afternoon's bout with Arizona at the Coliseum.
NFL point spread: The Rams opened as 10-point favorites; the total was 47.5 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 24.