The groin injury to tailback will no doubt have an immediate impact for plenty of fantasy football leagues with the 2019 Pro Bowler ruled out for Sunday's game against the Atlanta Falcons.
He suffered the injury during the team's Week 5 game against the Seattle Seahawks and was out most of the second half.
Cook's absence is a prime opportunity for both Alexander Mattison and Mike Boone to step up in the backfield and earn some more carries for the time being.
Through Week 5, Mattison has 219 rushing yards and a touchdown while Boone has 19 rushing yards on two attempts, both taking place after Cook's injury last week.