Once the NFL trickled out some of the games before its full schedule release, it became clear who the Los Angeles Rams would host in the opening game of the 2022 NFL regular season.
The Denver Broncos with new quarterback Russell Wilson were an option for the Rams' opener, but the NFL said the Broncos would face the Rams on Christmas Day. The NFL usually steers clear of divisional games in the traditional Thursday night opener. That narrowed the probable list to one juicy, marquee matchup for Sept. 8 at SoFi Stadium: The reigning Super Bowl champion Rams hosting the Buffalo Bills, one of the top contenders for the crown in the NFL's upcoming season.