Despite winning 10 games, 2021 marked a down year for Clemson as the program failed to win the ACC championship for the first time since Florida State completed the three-peat in 2014. Oddsmakers expect Dabo Swinney will enjoy a bounce-back campaign and lead the Tigers to a potential 12th consecutive double-digit win season.
SI Sportsbook has installed the Tigers as prohibitive -143 favorites in an ACC conference that is more wide open than the betting odds indicate.
Clemson, the ACC champions in seven of the last 11 seasons, is tied for the fourth-lowest odds to win the national championship at +1200.