Britain's Alastair Gray was beaten in straight sets in the Wimbledon second round by 11th seed Taylor Fritz.
The 24-year-old served for the second set but ultimately lost 6-3 7-6 (7-3) 6-3 to the American on court 12.
Fritz, 24, will face Slovakia's Alex Molcan in the third round.
Gray was the first of six Britons playing in the singles on Thursday, with Katie Boulter, Heather Watson, Harriet Dart, Liam Broady and Jack Draper also in action.
Boulter faces 2021 finalist Karolina Pliskova in the first match on Centre Court, while Watson will resume her second-round match against Wang Qiang after darkness forced it to be suspended on Wednesday with the Briton leading 7-5 5-4.