Kyle Edmund was the first Briton to be knocked out on day one of Wimbledon after a straight-sets defeat by France's Adrian Mannarino.
The British number three, 21, lost 6-2 7-5 6-4 in two hours and two minutes to the world number 55.
Defeat means the Yorkshireman is still searching for his maiden win in the men's singles at Wimbledon.
Eight other Britons - including former British number one Laura Robson - are also playing on the opening day.
Edmund had the honour of being the first home player to walk out on to court, but was unable to provide a winning start for a partisan crowd on Court Two.